The Hotel New Hampshire takes a look at quirky Americana and The Berrys are headed by Mr. Win Berry (Beau Bridges). With his wife (Lisa Banes), he has a created a large family with many children, none of whom are the least bit normal. John (Rob Lowe) is the athletic football player and womanizer with a deep-rooted desire for his own sister Frannie (Jodie Foster), a victim of a gang rape, now morbidly fascinated by one of the rapists, and equally attracted to her brother with incestuous desire. Frank (Paul McCrane) is their gay younger brother; and Lilly (Jennifer Dundas) is the little sister who blossoms into a famous author. Associated with the family is Suzie the Bear (Nastassja Kinski) who is not secure enough to come out of her bear suit. A friend of the family, Freud (Wallace Shawn), who has been blinded by the Nazis, runs the Hotel New Hampshire in Vienna. In need of help, he asks the family to come to his aid.